新的细胞毒药物如紫杉醇类、拓扑异构酶抑制剂及新联合方案是研究的热点；
急性淋巴细胞白血病患者DNA拓扑异构酶的表达及临床意义
1·In addition, the paper reviewed screening methods for differentiation inducers, DNA topoisomerase inhibitors, antimicrotubule drugs and biological response modifiers.
还对分化诱导剂、拓扑异构酶抑制剂、抗微管药和生物反应调节剂的筛选方法进行了评述。
2·Purpose to investigate the relationship between DNA topoisomerase and cell proliferation, apoptosis in ovarian carcinomas.
目的：探讨DNA拓扑异构酶在卵巢浆液性、黏液性囊腺癌中的表达及与细胞增殖、凋亡的关系。
3·AIM: to study the effects of shikonin on the catalytic activity of DNA topoisomerase I and apoptosis of K562 leukemia cells.
目的：研究紫草素对DNA拓扑异构酶i催化活性和K5 6 2白血病细胞凋亡的影响。
4·Mutation of type II topoisomerase gene;
拓扑异构酶II基因突变；