在抑郁症自杀者中突触后正面皮质中的CRF受体下调。
青春期精索静脉曲张对大鼠睾丸的影响与表皮生长因子的变化
1·Levels of cyclin D protein drop upon withdrawal of growth factors through downregulation of its protein expression and through phosphorylation-dependent degradation (4).
生长因子退出后，通过下调蛋白表达和磷酸化依赖性蛋白降解，周期蛋白D的水平下降（4）。
2·Downregulation of these pathways in normal organs can lead to vascular disturbances and even regression of blood vessels, which could be intensified by concurrent pathological conditions.
在正常器官中，这些信号途径下调能导致血管紊乱，甚至血管衰退，而且这些都可能由于同时发生的病理状态而加重。